• About me

    Now

    I'm a Principal Data Scientist at Dyno Therapeutics, where I am the computational lead for the design of viral vectors that target the brain. I use Machine Learning (and other methods) to design proteins, create high throughput screens and develop computational methods to analyze sequencing data.

    Before

    Previously, I worked at ConcertAI, using messy patient health and genomic data to help deliver personalized medicine.

     

    From 2019-2020, I led a data science team at Acorns in combating fraud, preventing overdrafts, targeting ads and recommending deals.

     

    In 2018, I spent a stint helping start Octant Inc. which uses technology I developed in my post-doc to test drugs against medicinally relevant cell receptors in parallel.

     

    I was a Fellow of The Jane Coffin Childs Memorial Fund for Medical Research at UCLA in the Kosuri Lab. I developed a massively parallel sequencing assay to understand how small molecules interact with the receptors that mediate smell. More generally, I am interested in using next-gen sequencing and mathematical analysis to define and then engineer new genotype-phenotype relationships.

     

    In May 2015, I finished my PhD at Harvard University in the Paulsson Lab. My thesis was on the control of mitochondrial DNA copy number, yeast polarity and RNA Polymerase dynamics. Before that, I received an A.B. in physics at Harvard College in 2007.

  • RESEARCH

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    Massively multiplex measurements of phenotype-genotype relationship using deep sequencing.

    Replacing traditional assays with next-generation sequencing allowed us to measure the responses of large numbers of smell receptors to a chemical at the same time. Eventually, this type of data will allow us to predict which chemicals hit which receptors.

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    Mitochondrial DNA copy number control

    How does mitochondrial DNA control replication to double each cell cycle and then divide between daughter cells at division? A paper on this work can be found here (or pdf). You can also read about it in my thesis.

  • Publications

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    Eric M Jones*, Rishi Jajoo*, Daniel Cancilla, Nathan B Lubock, Jeff Wang, Megan Satyadi, Rocky Cheung, Claire de March, Hiroaki Matsunami, Sriram Kosuri

    bioRxiv 358739; https://doi.org/10.1101/358739 and in review

    (* Indicates shared first-authorship)

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    Rishi Jajoo, Yoonseok Jung, Dann Huh, Matheus Viana, Susanne Rafelski, Michael Springer, and Johan Paulsson

    Science. 8 January 2016. Vol. 351 no. 6269 pp. 169-172
    DOI: 10.1126/science.aaa8714

    (pdf) (Supplement)

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    Martin Lukačišin*, , Matthieu Landon* and Rishi Jajoo*† PLoS ONE 12(3): e0174066. doi:10.1371/journal.pone.0174066 (2017)

    (* Indicates shared first-authorship)

    († Indicates corresponding author)

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    Kalin Vetsigian, Rishi Jajoo, Roy Kishony

    PLoS Biol 9(10): e1001184. doi:10.1371/journal.pbio.1001184 (2011)

  • CONTACT

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    [rjajoo] [at] [gmail] [dot] [com]

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